C.I. Food Blue 1
Indigo Carmine
CAS: 860-22-0
Molecular Formula: C16H8N2Na2O8S2
C.I. Food Blue 1 - Names and Identifiers
| Name | Indigo Carmine |
| Synonyms | E 132 C.I. 75781 Acid Blue 74 Indigo Carmine C.I. Food Blue 1 C.I. Acid Blue 74 C.I. Natural Blue 2 C.I. Food Blue 1, disodium salt disodium 5,5-indigodisulphonate Indigotindisulfonate Sodium [USAN] 5,5-Indigodisulfonic acid, disodium salt Indigo-5,5-disulphonic acid disodium salt disodium (2E)-3,3-dioxo-1,1,3,3-tetrahydro-2,2-biindole-5,5-disulfonate disodium 5,5-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate 1H-indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, disodium salt, (2E)- |
| CAS | 860-22-0 |
| EINECS | 212-728-8 |
| InChI | InChI=1/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17-18H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2/b14-13+; |
C.I. Food Blue 1 - Physico-chemical Properties
| Molecular Formula | C16H8N2Na2O8S2 |
| Molar Mass | 466.35 |
| Density | 1.01 g/mL at 20 °C |
| Melting Point | >300°C |
| Water Solubility | 1 g/100 mL (25℃) |
| Appearance | Form Powder/Solid, color Very dark blue to purple |
| PH | 7 (10g/l, H2O, 20℃) |
| Storage Condition | room temp |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| MDL | MFCD00005723 |
| Physical and Chemical Properties | Chemical properties dark green powder or particles. Soluble in water, slightly soluble in ethanol. |
| Use | For oxidant reduction indicator and biological stain, also for the determination of renal function |
C.I. Food Blue 1 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | DU3000000 |
| TSCA | Yes |
| HS Code | 32041200 |
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
C.I. Food Blue 1 - Upstream Downstream Industry
C.I. Food Blue 1 - Reference
| Reference Show more | 1. Xu Defeng Ye Ri-Ying Li Rainbow Sun Li army Wang Yaling mo ri Jian Yang Bridge. Bacillus sp. Effects of CAMT22370 glucose oxidase on storage performance of Penaeus vannamei [J]. Food Science, 2017, 38(21):259-264. 2. Quan Shujing, Hu Hong, Jie Fuhong, Tong Wentao, Zhang Xiu Jiang, du Zhi-min, Chen Guo-Shen. Screening, identification and characterization of extracellular glucose oxidase producing strain [J]. China Brewing, 2020,39(11):58-61. Note: For some products, our company can only provide some information, we do not guarantee the authority of the information provided, only for the reference of the customer. use: This product is for scientific research only, not for other purposes. (The following uses are for reference only) nickel's body and nuclear staining; Determination of high cerium, manganese, nitrate, sulfite, chlorate and milk; Acid-base indicator, redox indicator. storage conditions: 2-8℃ sensitivity: sensitive to light Appearance: dark blue powder wavelength: λmax 608 nm 1g soluble in about 100ml,25 C water, the solubility of water is lower than other edible synthetic pigment, 0 05% aqueous solution is blue. Long-term fading due to oxidation. Soluble in glycerol, propylene glycol, ethanol-soluble, insoluble in oil. In the case of concentrated sulfuric acid was dark blue, diluted blue, its aqueous solution with sodium hydroxide was green to yellow green. Light resistance and poor heat resistance, citric acid; Tartaric acid and alkali unstable. |
C.I. Food Blue 1 - Uses and synthesis methods
identification test
Solubility soluble in water; insoluble in ethanol. Measured according to OT-42 method.
pigment identification test shall be determined by OT-16 method.
content analysis
according to method 2 in the OT-15, the sample volume is 1.4~1.5g, and the buffer solution is prepared from 15g sodium hydrogen tartrate. TiCl3 per mL0.1mol/L is equivalent to 0.02883g of the total pigment.
Toxicity
ADI 0~5 mg/kg(FAO/WHO,2001).
LD50>2500mg/kg (mice, oral).
Toxicity
ADI is not specified (FAO/wH0,2001). 0~5(EEC,1990, tentative). Norway, Switzerland, Finland, Japan, Canada, and the United States are not allowed.
use limited
GB 2760-2001(g/kg): stained side dishes 0.01; Juice (flavor) drinks, carbonated drinks, prepared wine, candy, colored cakes on cakes, canned dyed cherries (for decoration), green plums, candy coating, wafer biscuit sandwich, 0.10; Red and green silk 0.20; Puffed food, fried food, 0.05.
use
1. Coloring for food, medicine and daily cosmetics. Edible indigo is a synthetic pigment for food. Food pigments are a class of additives used for food coloring, including synthetic pigments and natural pigments, totaling more than 60 kinds.
2. Used for oxidant reduction indicators and biological stains, and also used for the determination of renal function
3. food blue pigment. Generally used for color mixing. Because of its instability, low fastness, weak dyeing, the most suitable for dark tone. Adjustable to make chocolate, green, red bean, brown and brown. For cakes, cold drinks and cool drinks, the dosage is 5~100mg/kg.
4. as a food colorant, China stipulates that it can be used in red and green silk with a maximum usage of 0.20 g/kg; In fruit juice (flavor) drinks, carbonated drinks, prepared wine, candy, colored cakes, dyed canned cherries (for decoration) and green plums, the maximum usage is 0.10 g/kg; The maximum usage in dipped side dishes is 0.01 g/kg.
5. Redox indicator. Reagents for testing nitrate and chlorate in milk. Biological stains, such as Nikki's body, cell nucleus. Determination of renal function, etc.
production method
1. indigo preparation
Edible indigo is actually disodium indigo disulfonic acid, sulfonated by indigo with concentrated sulfuric acid, diluted with water after sulfonation, neutralized with soda ash, and finally added sodium chloride salted out, filtered, washed and dried to obtain the finished product. Preparation of indigo aluminum lake
aluminum hydroxide is prepared from aluminum salt such as aluminum chloride, aluminum sulfate and alkali such as sodium carbonate, and then added to indigo aqueous solution to precipitate the product.
2. Use concentrated sulfuric acid or a small amount of fuming sulfuric acid to make indigo blue. After sulfonation, it is diluted with water, neutralized by sodium carbonate or sodium hydroxide, salted out with sodium sulfate or sodium chloride, and then refined.
3. it is obtained by sulfonating indigo powder with concentrated sulfuric acid, diluting with water, neutralizing with sodium carbonate, salting out and refining. Each ton of product consumes 210kg of indigo powder (100%).
4. From dimethylaminodiphenylmethanol and 2-hydroxynaphthalene-3, 6-disulfonic acid, in the presence of concentrated sulfuric acid, lose one molecule of water to synthesize a colorless matrix, in a weak acid solution Oxidizing with manganese dioxide to triaryl methane pigment.
Diphenylmethanol is obtained by oxidizing tetraalkyldiaminodiphenylmethane with manganese dioxide and sulfuric acid. Condensation can be performed directly using its centrifugally separated filter cake. Manganese dioxide is freshly prepared from manganese sulfate and potassium permanganate in sodium carbonate solution.
Last Update：2024-05-09 12:23:31
C.I. Food Blue 1 - Security information
| toxic substance data | 860-22-0(Hazardous Substances Data) |
Last Update：2024-05-09 12:24:04
C.I. Food Blue 1 - Nature
| color index | 73015 |
| Odor | Light odour |
| pH range of acid-base indicator discoloration | 11.5(blue)-14.0(yellow) |
| maximum wavelength (& lambda;max) | 608nm |
| sensitivity | Light Sensitive |
| Merck | 14,4944 |
| BRN | 4103904 |
| biological applications | Detecting microorganisms; treating amyloidosis,testicular cancer; medical devices; drug delivery system |
| main applications | Display device, sensor, chemical-mechanical polishing, batteries, photographic materials, thermoplastics, inks, highlighters, detergents, disinfectants, rodenticide, colored bubbles, hair dyes, cosmetics, food, determine bacterial growth, antiischemic Magents, antiseptic, antitumor agents, Alzheimer's disease, psychoactive drugs, Tooth whitening |
| EPA chemical information | C. I. Acid Blue 74 (860-22-0) |
Last Update：2024-05-09 12:26:23
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View History
Raw Materials for C.I. Food Blue 1
Sodium sulfate
Potassium permanganate
Manganese dioxide
Aluminum hydroxide
Aluminum sulfate
Sulfurous Acid
Food Blue 1:1
Indigo
Potassium permanganate
Manganese dioxide
Aluminum hydroxide
Aluminum sulfate
Sulfurous Acid
Food Blue 1:1
Indigo
Downstream Products for C.I. Food Blue 1